Tau and Alzheimer's disease
Alzheimer's disease (AD) is an insidious progressive neurodegenerative disease. Clinically, alzheimer's disease has become a major threat to the health of human beings, especially the elderly, characterized by the manifestations of comprehensive dementia, such as memory impairment, aphasia, apraxia, agnosia, impaired visuospatial skills, executive dysfunction, and personality and behavior change.
A new study found that the microglia can cause brain damage brain immune cells can be activated with the accumulation of tau tangles, further studies have found that by eliminating such cells can significantly reduce the associated tau protein in mice caused by brain damage, and can inhibit the prevent or delay the onset of dementia.
Normally, tau helps neurons in the brain function normally and healthily. In some people, however, it can gather in toxic tangles, causing microglia cells to attack, and later in the disease, once tau tangles form, cell attacks on tangles can damage nearby neurons and lead to neurodegeneration.
To further understand the role of microglia in tau driven neurodegeneration, the authors and their colleagues studied genetically modified mice that carry a mutant form of human tau. The researchers genetically modified mice to either carry a human variant of APOE4, which amplifies tau's toxic effect on neurons, or not carry the APOE gene.
Experiments have shown that microglia cells can cause neurodegeneration through the death of neurons caused by inflammation. In this case, if there are no microglia cells, or if there are microglia cells but they can't be activated, the harmful tau won't accumulate and develop to an advanced stage, and the nervous system won't be damaged. The findings suggest that microglia cells are key to neurodegenerative disease -- and an attractive target for preventing cognitive decline in alzheimer's disease, chronic traumatic encephalopathy, and other neurodegenerative diseases.
For many years, Wuxi Donglin Sci & Tech Development Co.,Ltd's technical personnel have been dedicated to the research, development and production of high quality immunoassay reagent. We provide outstanding products to scientists in the life sciences worldwide and have become a reliable supplier to many leading international research institutions and clinical diagnostic companies.
If you are interested in our ELISA Kits, you can directly visit our website:
http://www.dldevelop.com
A new study found that the microglia can cause brain damage brain immune cells can be activated with the accumulation of tau tangles, further studies have found that by eliminating such cells can significantly reduce the associated tau protein in mice caused by brain damage, and can inhibit the prevent or delay the onset of dementia.
Normally, tau helps neurons in the brain function normally and healthily. In some people, however, it can gather in toxic tangles, causing microglia cells to attack, and later in the disease, once tau tangles form, cell attacks on tangles can damage nearby neurons and lead to neurodegeneration.
To further understand the role of microglia in tau driven neurodegeneration, the authors and their colleagues studied genetically modified mice that carry a mutant form of human tau. The researchers genetically modified mice to either carry a human variant of APOE4, which amplifies tau's toxic effect on neurons, or not carry the APOE gene.
Experiments have shown that microglia cells can cause neurodegeneration through the death of neurons caused by inflammation. In this case, if there are no microglia cells, or if there are microglia cells but they can't be activated, the harmful tau won't accumulate and develop to an advanced stage, and the nervous system won't be damaged. The findings suggest that microglia cells are key to neurodegenerative disease -- and an attractive target for preventing cognitive decline in alzheimer's disease, chronic traumatic encephalopathy, and other neurodegenerative diseases.
For many years, Wuxi Donglin Sci & Tech Development Co.,Ltd's technical personnel have been dedicated to the research, development and production of high quality immunoassay reagent. We provide outstanding products to scientists in the life sciences worldwide and have become a reliable supplier to many leading international research institutions and clinical diagnostic companies.
If you are interested in our ELISA Kits, you can directly visit our website:
http://www.dldevelop.com
